As expected, there was a significant increase in overall spine density in NAc slices from cocaine-treated WT mice at this time-point, however, there was a greater increase in the density of mushroom spines in β Add KO animals following chronic cocaine administration compared to WT. The effect of 10 days of daily cocaine (15 mg/kg) administration on NAc spine number and locomotor behavior was also measured in β Add WT and knockout (KO) mice. ![]() Using diolistic labeling with the lipophilic dye DiI, we found that the density of mature mushroom-shaped spines was significantly decreased in the nucleus accumbens (NAc) in brain slices from βAdd KO mice as compared to their wildtype (WT) siblings. Beta adducin ( βAdd) is involved in synaptic plasticity in the hippocampus however, the role of βAdd in synaptic plasticity in other brain areas is unknown. ![]() ![]() The adducin family of proteins associates with the actin cytoskeleton in a calcium-dependent manner.
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